Hydrochloric Acid → 4-(2-Aminothiazol-4-yl)butanoic acid hydrochloride

HRID 618135Notes

Reaction equation

HRID 618135 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][CH2:8][CH2:9][C:10]([O:12]C)=[O:11])[N:6]=1.[ClH:14]>>[ClH:14].[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[N:6]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21699734Methyl 4-(2-amino-1,3-thiazol-4-yl)butanoate

Product 1

HCID 867544654-(2-Aminothiazol-4-yl)butanoic acid hydrochloride

Procedure

Ester 1-3 (1.3 g, 6.5 mmol) was dissolved in 32 mL 6 N HCl. After stirring overnight, the resulting suspension was concentrated, providing acid 1-4 as a white solid.

Workup

  1. concentrationthe resulting suspension was concentrated

Sources & evidence

ORD record
ord-5f81402a248b4838b1032fdcdb61eadb
Source dataset
uspto-grants-1999_09
Patent number
US05952306

Reaction notes

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