HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethanol ammonium hydroxide water
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(Pyridin-4-yl)butanoyl-sarcosine 3(R)-[2-(indol-3-yl)ethyl]-beta-alanine ethyl ester | HCID 86754477 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethanol ammonium hydroxide water | HCID 86596525 | — |
| Product | EtOAc EtOH H2O NH4OH | HCID 86752451 | — |
Reaction Steps
Ester 6-3 (400 mg, 0.84 mmol) was dissolved in 4 mL EtOH, then 1 N NaOH (1.7 mL, 1.7 mmol) was added. After 90 min the reaction was neutralized with 1 N HCl (1.7 mL, 1.7 mmol) and concentrated to an oil. Flash chromatography (silica, 50:1:1 EtOH/H2O/NH4OH, then again with 12:10:1:1 EtOAc/EtOH/H2O/NH4OH) provided 6-4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05952306 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-d26163a8c4e647079453041d3440bcd0 |
| Source note | uspto-grants-1999_09 |