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HRID618151

反应详情

EQUATION

反应方程式

HRID 618151 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：CCOC(=O)C[C@H](N)CCc1c[nH]c2ccccc12.CN(CC(=O)O)C(=O)CCCc1ccncc1
HCID86754477

未命名化合物

PRODUCTS

生成物

2
结构：CCO.O.[NH4+].[OH-]
HCID86596525

Ethanol ammonium hydroxide water

C2H13NO3

结构：CCO.CCOC(C)=O.O.[NH4+].[OH-]
HCID86752451

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Ester 6-3 (400 mg, 0.84 mmol) was dissolved in 4 mL EtOH, then 1 N NaOH (1.7 mL, 1.7 mmol) was added. After 90 min the reaction was neutralized with 1 N HCl (1.7 mL, 1.7 mmol) and concentrated to an oil. Flash chromatography (silica, 50:1:1 EtOH/H2O/NH4OH, then again with 12:10:1:1 EtOAc/EtOH/H2O/NH4OH) provided 6-4.

WORKUP

后处理

  1. concentrationconcentrated to an oil