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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 618169Generated: October 25, 2026

4-Chloropyridine hydrochloride → Ethyl 1-(pyridin-4-yl)piperidine-3-carboxylate

https://huagongshe.com/reaction/618169

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloropyridine hydrochlorideHCID 81852—
ReactantEthyl nipecotateHCID 98969—
ProductEthyl 1-(pyridin-4-yl)piperidine-3-carboxylateHCID 12895985—

Reaction Steps

Ethyl (±) nipecotate (7.0 g, 44.53 mmol) was reacted with 4-chlorpyridine hydrochloride (6.67 g, 44.53 mmol) as described for 21-1 to give the title compound as a yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05952306
Source datasetuspto-grants-1999_09
ORD IDord-26e79f4e36684986aacbd8850f0cbbfc
Source noteuspto-grants-1999_09