4-Chloropyridine hydrochloride → Ethyl 1-(pyridin-4-yl)piperidine-3-carboxylate

HRID 618169Notes

Reaction equation

HRID 618169 reaction equation
[NH:1]1[CH2:11][CH2:10][CH2:9][CH:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH2:2]1.Cl.Cl[C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1>>[N:17]1[CH:18]=[CH:19][C:14]([N:1]2[CH2:11][CH2:10][CH2:9][CH:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH2:2]2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 818524-Chloropyridine hydrochlorideHCID 98969Ethyl nipecotate

Product 1

HCID 12895985Ethyl 1-(pyridin-4-yl)piperidine-3-carboxylate

Procedure

Ethyl (±) nipecotate (7.0 g, 44.53 mmol) was reacted with 4-chlorpyridine hydrochloride (6.67 g, 44.53 mmol) as described for 21-1 to give the title compound as a yellow solid.

Sources & evidence

ORD record
ord-26e79f4e36684986aacbd8850f0cbbfc
Source dataset
uspto-grants-1999_09
Patent number
US05952306

Reaction notes

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