Sulfur → HCID 59968960, compound

HRID 618178Notes

Reaction equation

HRID 618178 reaction equation
[CH3:1][O:2][C:3](=[O:34])[CH2:4][C@H:5]([NH:12][C:13](=[O:33])[CH2:14][NH:15][C:16](=[O:32])[CH2:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]([NH:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[NH2:31])=S)[C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1.[S]>C(O)C>[CH3:1][O:2][C:3](=[O:34])[CH2:4][C@H:5]([NH:12][C:13](=[O:33])[CH2:14][NH:15][C:16](=[O:32])[CH2:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]1[NH:31][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[N:24]=1)[C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 5362487SulfurHCID 54146754HCID 54146754, compound

Product 1

HCID 59968960HCID 59968960, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

An ethanol mixture(20 ml) of 24-7 (89 mg, 0.18 mmol), mercuric oxide (78.8 mg, 0.36 mmol) and sulfur (1.8 mg, 0.056 mmol) was refluxed for 2 hr. After cooling, the mixture was filtered and the filtrate concentrated to a semi-solid which was purified by flash chromatography (20% MeOH/CH2Cl2) to provide 24-8 as a solid.

Workup

  1. temperatureAfter cooling
  2. filtrationthe mixture was filtered
  3. concentrationthe filtrate concentrated to a semi-solid which
  4. customwas purified by flash chromatography (20% MeOH/CH2Cl2)

Sources & evidence

ORD record
ord-bc76c41369d14b57a06af620a0a01534
Source dataset
uspto-grants-1999_09
Patent number
US05952306

Reaction notes

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