反应详情

温度

75 °C

2,6-Dimethyl-3-nitrobenzoic acid (10 g) was dissolved in 100 ml of dry tetrahydrofuran and 165 ml of 1M borane in tetrahydrofuran added. The mixture was heated to 75° C. for 4 hr. The mixture was cooled to room temperature and the excess reagent slowly decomposed with water and the solvent evaporated. The residue was treated with ethyl acetate, washed with 1M hydrochloric acid, then with water, dried, and evaporated to give 8.71 g of (2,6-dimethyl-3-nitro-phenyl)-methanol, mp 94.5-96.1° C. ##STR124##

1. temperatureThe mixture was cooled to room temperature
2. customthe solvent evaporated
3. additionThe residue was treated with ethyl acetate
4. washwashed with 1M hydrochloric acid
5. dry with materialwith water, dried
6. customevaporated