HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 1,1-Dioxido-2-(4-(4-(3-ethyl-2-oxo-1-benzimidazolinyl)piperidin-1-yl)butyl)-1,2-benzisothiazol-3(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 1,1-Dioxido-2-(4-bromobutyl)-1,2-benzisothiazol-3(2H)-one | HCID 10781774 | — |
| Reactant | 1-Ethyl-3-piperidin-4-ylbenzimidazol-2-one | HCID 18695946 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1,1-Dioxido-2-(4-(4-(3-ethyl-2-oxo-1-benzimidazolinyl)piperidin-1-yl)butyl)-1,2-benzisothiazol-3(2H)-one | HCID 15872114 | — |
Reaction Steps
From 4-(3-ethyl-2-oxo-1-benzimidazolinyl)piperidine and 1,1-dioxido-2-(4-bromobutyl)-1,2-benzisothiazol-3(2H)-one (prepared as shown in Example 21) using the procedures described in Example 1 there was obtained a white solid as the freebase (from diethyl ether), melting point 124-25° C. Analysis calculated for C25H30N4O4S.0.4 H2O: C, 61.30; H, 6.34; N, 11.44; found: C, 61.34; H, 6.18; N, 11.47. The NMR was consistent with the structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05952351 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-ee5939670dc24ba6a31964f692a80682 |
| Source note | uspto-grants-1999_09 |