1-(Piperidin-4-yl)-3-propyl-1,3-dihydro-2H-benzimidazol-2-one → 1,1-Dioxido-2-(4-(4-(3-n-propyl-2-oxo-1-benzimidazolinyl)piperidin-1-yl)pentyl)-5-chloro-1,2-benzisothiazol-3(2H)-one

HRID 618375Notes

Reaction equation

HRID 618375 reaction equation
[CH2:1]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]([CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[C:5]1=[O:19])[CH2:2][CH3:3].[O:20]=[S:21]1(=[O:38])[C:25]2[CH:26]=[CH:27][C:28]([Cl:30])=[CH:29][C:24]=2[C:23](=[O:31])[N:22]1[CH2:32][CH2:33][CH2:34][C:35](=O)[CH3:36]>>[O:38]=[S:21]1(=[O:20])[C:25]2[CH:26]=[CH:27][C:28]([Cl:30])=[CH:29][C:24]=2[C:23](=[O:31])[N:22]1[CH2:32][CH2:33][CH2:34][CH:35]([N:16]1[CH2:17][CH2:18][CH:13]([N:6]2[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:4]([CH2:1][CH2:2][CH3:3])[C:5]2=[O:19])[CH2:14][CH2:15]1)[CH3:36]

Participants

3

Reactant 2

HCID 158951351-(Piperidin-4-yl)-3-propyl-1,3-dihydro-2H-benzimidazol-2-oneHCID 186959791,1-dioxido-2-(4-oxo-pentyl)-5-chloro-1,2-benzisothiazol-3(2H)-one

Product 1

HCID 186959671,1-Dioxido-2-(4-(4-(3-n-propyl-2-oxo-1-benzimidazolinyl)piperidin-1-yl)pentyl)-5-chloro-1,2-benzisothiazol-3(2H)-one

Procedure

Starting with 4-(3-n-propyl-2-oxo-1-benzimidazolinyl)piperidine and 1,1-dioxido-2-(4-oxo-pentyl)-5-chloro-1,2-benzisothiazol-3(2H)-one and following the procedure of Example 13, the title compound is obtained.

Sources & evidence

ORD record
ord-14472566878a49b38528865ec60c8a7c
Source dataset
uspto-grants-1999_09
Patent number
US05952351

Reaction notes

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