HCID 21850854, compound → HCID 21850845, compound

HRID 618443Notes

Reaction equation

HRID 618443 reaction equation
C(O[C:4]([C:6](=[CH:12][NH:13][C:14]1[C:15]([O:20][CH3:21])=[N:16][CH:17]=[CH:18][CH:19]=1)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5])C>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH3:21][O:20][C:15]1[N:16]=[CH:17][CH:18]=[C:19]2[C:14]=1[NH:13][CH:12]=[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[C:4]2=[O:5]

Participants

3

Reactant 1

HCID 21850854HCID 21850854, compound2×

Product 1

HCID 21850845HCID 21850845, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Conditions

Temperature
60 °C

Procedure

28.5 g of ethyl 2-ethoxycarbonyl-3-(2-methoxypyridin-3-yl)aminoacrylate prepared in the above (A) was dissolved in 150 ml of diphenyl ether, and the resulting solution was heated to reflux for 1.5 hours and cooled to about 60° C. Petroleum ether was added to give precipitates, which were filtered to give 14.1 g (59%) of the titled compound as brown crystals.

Workup

  1. temperaturethe resulting solution was heated
  2. temperatureto reflux for 1.5 hours
  3. customto give
  4. customprecipitates
  5. filtrationwhich were filtered

Sources & evidence

ORD record
ord-c33081046e074533ada2db4ddcd8c4cd
Source dataset
uspto-grants-1999_09
Patent number
US05952504

Reaction notes

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