HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Glutamic Acid → [[(2,4-Diamino-6-Pteridinyl)Methyl]Methyl Amino] Benzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Glutamic Acid | HCID 33032 | — |
| Reactant | Methotrexate | HCID 126941 | — |
| Product | [[(2,4-Diamino-6-Pteridinyl)Methyl]Methyl Amino] Benzoic Acid | HCID 70031183 | — |
Reaction Steps
The title compound was prepared by carboxypeptidase G cleavage of glutamic acid from methotrexate as described in the literature (J. Med. Chem. 24, 1450-1455 (1981)). The yield of I obtained was virtually quantitative.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05952499 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-c57135597378462697ba70197b1c3f36 |
| Source note | uspto-grants-1999_09 |