反应详情

温度

160 °C

Mixture of 3-fluoro-8-methoxy-6,6-dimethyl-5,6-dihydro-benzo[b]carbazol-11-one (Compound V3, 56.6 mg, 0.183 mmol) and pyridinium chloride (0.65 g) was stirred at ambient temperature of 160° C. for 12 hr. The reaction mixture was cooled to room temperature, added with ethyl acetate and water, and the resulting mixture was extracted four times with ethyl acetate. The organic layer was washed with water three times, dried over sodium sulfate, and concentrated under reduced pressure. The obtained crude product was used for the next step without further purification (brown solid, 61.6 mg, 100%).

1. temperatureThe reaction mixture was cooled to room temperature
2. extractionthe resulting mixture was extracted four times with ethyl acetate
3. washThe organic layer was washed with water three times
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated under reduced pressure
6. customThe obtained crude product
7. customwas used for the next step without further purification (brown solid, 61.6 mg, 100%)