Diethyl Ether → HCID 21848303, compound

HRID 618710Notes

Reaction equation

HRID 618710 reaction equation
[F:1][C:2]1[C:3]([F:14])=[CH:4][C:5]2[O:9][C:8]([C:10]([NH2:12])=[NH:11])=[CH:7][C:6]=2[CH:13]=1.C(OCC)C.[ClH:20].CO>>[ClH:20].[F:1][C:2]1[C:3]([F:14])=[CH:4][C:5]2[O:9][C:8]([C:10]([NH2:12])=[NH:11])=[CH:7][C:6]=2[CH:13]=1

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 15434546HCID 15434546, compoundHCID 21893726Hydrochloride methanol

Product 1

HCID 21848303HCID 21848303, compoundYield 87%

Procedure

0.55 g (2.8 mmol) of 5,6-difluorobenzofuran-2-carboxamidine was dissolved in 10 ml of methanol-HCI (2.6N) and treated at room temperature while stirring with 100 ml of diethyl ether. The mixture was stirred for a further 3 hours and the white crystals were subsequently filtered off. There was obtained 0.61 g (87%) of 5,6-difluorobenzofuran-2-carboxamidine hydrochloride with m.p. >270°.

Workup

  1. additiontreated at room temperature
  2. filtrationthe white crystals were subsequently filtered off

Sources & evidence

ORD record
ord-a6f99d8911dd458dba272651387382b3
Source dataset
uspto-grants-1999_09
Patent number
US05955495

Reaction notes

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