Ammonia → HCID 15859751, compound

HRID 618806Notes

Reaction equation

HRID 618806 reaction equation
[CH2:1]([S:3]([N:6]([CH:15]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([CH3:25])[CH:23]=2)[O:18][C:17]([CH3:27])([CH3:26])[CH2:16]1)[CH2:7][CH2:8][CH2:9][CH2:10][C:11](OC)=[O:12])(=[O:5])=[O:4])[CH3:2].[NH3:28]>CO>[CH2:1]([S:3]([N:6]([CH:15]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([CH3:25])[CH:23]=2)[O:18][C:17]([CH3:27])([CH3:26])[CH2:16]1)[CH2:7][CH2:8][CH2:9][CH2:10][C:11]([NH2:28])=[O:12])(=[O:5])=[O:4])[CH3:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 21848681HCID 21848681, compound

Product 1

HCID 15859751HCID 15859751, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 0.4 g (1 mmol) of methyl 5-[ethylsulfonyl-(2,2,6-trimethyl-chroman-4-yl)amino]pentanoate and 1.5 ml of liquid ammonia in 10 ml of methanol is allowed to stand at RT for 9 days. After concentrating in vacuo, the residue is treated with water and extracted with EA. 0.37 g of 5-[ethylsulfonyl-(2,2,6-trimethylchroman-4-yl)amino]pentanamide is obtained; m.p. 127-129° C.

Workup

  1. concentrationAfter concentrating in vacuo
  2. additionthe residue is treated with water
  3. extractionextracted with EA

Sources & evidence

ORD record
ord-3838ea6664b64db2a48a532c1f5f9357
Source dataset
uspto-grants-1999_09
Patent number
US05955607

Reaction notes

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