Hydrochloric Acid → HCID 21848652, compound

Participants

Reaction Steps

0.5 g (1.25 mmol) of methyl 5-[ethylsulfonyl-(2,2,6-trimethyl-chroman-4-yl)amino]pentanoate (Example 1d) is stirred overnight at RT with 0.21 g (3.77 mmol) of KOH in 20 ml of methanol. After stripping off the solvent in vacuo, the residue is acidified with hydrochloric acid and extracted with EA. 0.4 g of 5-[ethylsulfonyl-(2,2,6-trimethylchroman-4-yl)amino]pentanoic acid is obtained.

Provenance & Evidence