Hydrochloric Acid → HCID 21848652, compound

HRID 618807Notes

Reaction equation

HRID 618807 reaction equation
[CH2:1]([S:3]([N:6]([CH:15]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([CH3:25])[CH:23]=2)[O:18][C:17]([CH3:27])([CH3:26])[CH2:16]1)[CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13]C)=[O:12])(=[O:5])=[O:4])[CH3:2].[OH-].[K+].Cl>CO>[CH2:1]([S:3]([N:6]([CH:15]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([CH3:25])[CH:23]=2)[O:18][C:17]([CH3:26])([CH3:27])[CH2:16]1)[CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])(=[O:5])=[O:4])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 21848681HCID 21848681, compound

Product 1

HCID 21848652HCID 21848652, compoundYield 83.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.5 g (1.25 mmol) of methyl 5-[ethylsulfonyl-(2,2,6-trimethyl-chroman-4-yl)amino]pentanoate (Example 1d) is stirred overnight at RT with 0.21 g (3.77 mmol) of KOH in 20 ml of methanol. After stripping off the solvent in vacuo, the residue is acidified with hydrochloric acid and extracted with EA. 0.4 g of 5-[ethylsulfonyl-(2,2,6-trimethylchroman-4-yl)amino]pentanoic acid is obtained.

Workup

  1. extractionextracted with EA

Sources & evidence

ORD record
ord-6d55a6118ef24b32a280d5b65514d597
Source dataset
uspto-grants-1999_09
Patent number
US05955607

Reaction notes

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