HCID 86754517, compound → HCID 21848664, compound

HRID 618814Notes

Reaction equation

HRID 618814 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[O:15][C:14]([CH3:20])([CH3:19])[CH2:13][CH:12]2[CH2:21][S:22]([NH:25][CH2:26][C:27]([O:29]C)=[O:28])(=[O:24])=[O:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[OH-].[Na+]>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[O:15][C:14]([CH3:20])([CH3:19])[CH2:13][CH:12]2[CH2:21][S:22]([NH:25][CH2:26][C:27]([OH:29])=[O:28])(=[O:24])=[O:23])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 86754517HCID 86754517, compound

Product 1

HCID 21848664HCID 21848664, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

1.4 g of methyl [(6-benzyloxy-2,2-dimethylchroman-4-yl)methanesulfonylamino]acetate are stirred at RT for 4 h in 50 ml of methanol and 15 ml of 2N NaOH. After removing the methanol, the residue is washed with EA and acidified with HCl. It is extracted with EA and the solvent is removed in vacuo after drying. 500 mg of the acid having a melting point of 167-169° C. are obtained.

Workup

  1. customAfter removing the methanol
  2. washthe residue is washed with EA
  3. extractionIt is extracted with EA
  4. customthe solvent is removed in vacuo
  5. customafter drying
  6. customare obtained

Sources & evidence

ORD record
ord-bed7002b47184ba0bdaeb69077251cda
Source dataset
uspto-grants-1999_09
Patent number
US05955607

Reaction notes

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