反应详情

To a solution of the mixture of methyl cyclopylacrylate and methyl 3-cyclopropyl-3-methoxypropionate (59.6 g, from Example 1, Example 2, Example 3 or Example 4) in methanol (120 ml) was added potassium carbonate (32.24 g) and stirred for 13 hours at room temperature. After addition of hexane, the upper hexane's layer was separated, filtered and concentrated. The residue was diluted with hexane, filtered, concentrated, and distill (50 mmHg, 101° C. to 102° C.) to give methyl cyclopropylacrylate (23.3 g, yield 62%).

1. customthe upper hexane's layer was separated
2. filtrationfiltered
3. concentrationconcentrated
4. additionThe residue was diluted with hexane
5. filtrationfiltered
6. concentrationconcentrated
7. distillationdistill (50 mmHg, 101° C. to 102° C.)