Hexane → HCID 11457694, compound

HRID 618859Notes

Reaction equation

HRID 618859 reaction equation
C1(C(OC)C[C:6]([O:8][CH3:9])=[O:7])CC1.C(=O)([O-])[O-].[K+].[K+].C[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]>CO>[CH:21]1([C:20](=[CH2:19])[C:6]([O:8][CH3:9])=[O:7])[CH2:22][CH2:23]1

Participants

5

Reactant 3

HCID 8058HexaneHCID 11430Potassium CarbonateHCID 10313241HCID 10313241, compound

Product 1

HCID 11457694HCID 11457694, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of the mixture of methyl cyclopylacrylate and methyl 3-cyclopropyl-3-methoxypropionate (59.6 g, from Example 1, Example 2, Example 3 or Example 4) in methanol (120 ml) was added potassium carbonate (32.24 g) and stirred for 13 hours at room temperature. After addition of hexane, the upper hexane's layer was separated, filtered and concentrated. The residue was diluted with hexane, filtered, concentrated, and distill (50 mmHg, 101° C. to 102° C.) to give methyl cyclopropylacrylate (23.3 g, yield 62%).

Workup

  1. customthe upper hexane's layer was separated
  2. filtrationfiltered
  3. concentrationconcentrated
  4. additionThe residue was diluted with hexane
  5. filtrationfiltered
  6. concentrationconcentrated
  7. distillationdistill (50 mmHg, 101° C. to 102° C.)

Sources & evidence

ORD record
ord-c2c05a10474b42738f9f3ab3cb47659c
Source dataset
uspto-grants-1999_09
Patent number
US05955627

Reaction notes

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