Piperazine → HCID 66835180, compound

HRID 61888Notes

Reaction equation

[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[C:7]3[C:8](=[O:30])[C:9]4[CH:21]=[CH:20][C:19](OS(C(F)(F)F)(=O)=O)=[CH:18][C:10]=4[C:11]([CH3:17])([CH3:16])[C:12]=3[NH:13][C:14]=2[N:15]=1)#[N:2].[NH:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>>[CH3:16][C:11]1([CH3:17])[C:12]2[NH:13][C:14]3[N:15]=[C:3]([C:1]#[N:2])[CH:4]=[CH:5][C:6]=3[C:7]=2[C:8](=[O:30])[C:9]2[CH:21]=[CH:20][C:19]([N:31]3[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]3)=[CH:18][C:10]1=2

Participants

Reactant 2

HCID 4837Piperazine

HCID 86663828Trifluoromethanesulfonic acid 2-cyano-10,10-dimethyl-5-oxo-10,11-dihydro-5H-1,11-diaza-benzo[b]fluoren-8-yl ester

Product 1

HCID 66835180HCID 66835180, compound

Procedure

According to the method used for synthesizing Compound B2-1, trifluoromethanesulfonic acid 2-cyano-10,10-dimethyl-5-oxo-10,11-dihydro-5H-1,11-diaza-benzo[b]fluoren-8-yl ester was introduced with piperazine to obtain the title compound.

Sources & evidence

ORD record: ord-5248883086fb4577bcbfc46f1914befa
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09440922B2

Reaction notes

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