Hydrochloric Acid → HCID 21844908, compound

HRID 618942Notes

Reaction equation

HRID 618942 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([NH:18][C:19]([C:21]2[CH:26]=[C:25]([C:27]([NH:29][CH:30]([CH2:33][OH:34])[CH2:31][OH:32])=[O:28])[CH:24]=[C:23]([N+:35]([O-])=O)[CH:22]=2)=[O:20])[CH:7]=[C:8]([C:10]([NH:12][CH:13]([CH2:16][OH:17])[CH2:14][OH:15])=[O:11])[CH:9]=1)([O-])=O.CO.[ClH:40]>[Pd].O>[ClH:40].[ClH:40].[NH2:1][C:4]1[CH:5]=[C:6]([NH:18][C:19]([C:21]2[CH:26]=[C:25]([C:27]([NH:29][CH:30]([CH2:33][OH:34])[CH2:31][OH:32])=[O:28])[CH:24]=[C:23]([NH2:35])[CH:22]=2)=[O:20])[CH:7]=[C:8]([C:10]([NH:12][CH:13]([CH2:14][OH:15])[CH2:16][OH:17])=[O:11])[CH:9]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 21844896HCID 21844896, compound

Product 1

HCID 21844908HCID 21844908, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

3-Nitro-5-(1,3-dihydroxyprop-2-ylaminocarbonyl)phenylaminocarbonyl-[3'-nitro-5'-(1,3-dihydroxyprop-2-ylaminocarbonyl)benzene] (1.03 g, 1.98 mmol) was hydrogenated in a solution containing methanol (40 ml), concentrated HCl (2 ml), water (2 ml) and a Pd/C catalyst (10%, 0.2 g) at 60 psi. The catalyst was filtered off and the solvent was evaporated. Water (150 ml) was then added and the solution was lyophilized. Yield: 0.98 g (93%).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was evaporated
  3. additionWater (150 ml) was then added

Sources & evidence

ORD record
ord-a857d708385f4a70b833cd386e4bbaf3
Source dataset
uspto-grants-1999_09
Patent number
US05958375

Reaction notes

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