3-Amino-1,2-propanediol → HCID 21844884, compound

HRID 618943Notes

Reaction equation

HRID 618943 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([NH:14][C:15]([C:17]2[CH:22]=[C:21]([C:23](OC)=[O:24])[CH:20]=[C:19]([N+:27]([O-:29])=[O:28])[CH:18]=2)=[O:16])[CH:7]=[C:8]([C:10](OC)=[O:11])[CH:9]=1)([O-:3])=[O:2].[NH2:30][CH2:31][CH:32]([OH:35])[CH2:33][OH:34]>>[N+:1]([C:4]1[CH:5]=[C:6]([NH:14][C:15]([C:17]2[CH:22]=[C:21]([C:23]([NH:30][CH2:31][CH:32]([OH:35])[CH2:33][OH:34])=[O:24])[CH:20]=[C:19]([N+:27]([O-:29])=[O:28])[CH:18]=2)=[O:16])[CH:7]=[C:8]([C:10]([NH:30][CH2:31][CH:32]([OH:35])[CH2:33][OH:34])=[O:11])[CH:9]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 735613-Amino-1,2-propanediolHCID 21844925HCID 21844925, compound

Product 1

HCID 21844884HCID 21844884, compound

Conditions

Temperature
90 °C

Procedure

3-Nitro-5-methoxycarbonylphenylaminocarbonyl-(3'-nitro-5'-methoxycarbonylbenzene) (1.21 g, 3.0 mmol) was suspended in aminopropan-2,3-diol (0.55 g, 6.0 mmol) and the mixture was heated to 90° C. After 30 min, the pressure was reduced to 200 mm Hg and heating was continued for 90 min. The product was purified by preparative HPLC. Yield: 0.73 g (47%).

Workup

  1. temperatureheating
  2. waitwas continued for 90 min
  3. customThe product was purified by preparative HPLC

Sources & evidence

ORD record
ord-631e4825415d449491fb7e58f5764ffd
Source dataset
uspto-grants-1999_09
Patent number
US05958375

Reaction notes

Loading…