Hydrazine hydrate (1:1) → HCID 178509277, compound

HRID 619021Notes

Reaction equation

HRID 619021 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[CH2:12][CH2:11][C:10]3[CH:13]=[C:14]([Cl:18])[CH:15]=[C:16]([Cl:17])[C:9]=3[CH:8]([CH:19]3[CH2:24][CH2:23][N:22]([C:25](=O)[CH2:26][CH:27]4[CH2:31][CH2:30][N:29]([C:32](=[N:40][C:41]#[N:42])OC5C=CC=CC=5)[CH2:28]4)[CH2:21][CH2:20]3)[C:5]2=[N:6][CH:7]=1.[OH2:44].[NH2:45][NH2:46]>CO>[Br:1][C:2]1[CH:3]=[C:4]2[CH2:12][CH2:11][C:10]3[CH:13]=[C:14]([Cl:18])[CH:15]=[C:16]([Cl:17])[C:9]=3[CH:8]([CH:19]3[CH2:24][CH2:23][N:22]([C:25](=[O:44])[CH2:26][CH:27]4[CH2:31][CH2:30][N:29]([C:32]5[NH:46][N:45]=[C:41]([NH2:42])[N:40]=5)[CH2:28]4)[CH2:21][CH2:20]3)[C:5]2=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 15435436HCID 15435436, compound

Product 1

HCID 178509277HCID 178509277, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

The product of Example 7 (1 equivalent) is dissolved in CH3OH. Hydrazine hydrate (1 equivalent) is added and the mixture is stirred at 25° C. for 1 h. The mixture is evaporated to dryness and chromatographed on silica gel to give the title compound.

Workup

  1. customThe mixture is evaporated to dryness
  2. customchromatographed on silica gel

Sources & evidence

ORD record
ord-eeaf228f56994dec84b2e4d6cb3f88c1
Source dataset
uspto-grants-1999_09
Patent number
US05958890

Reaction notes

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