反应详情

A mixture of 0.5 g of 4-(3-nitro-phenyl)-thiazol-2-ylamine hydrobromide with 0.21 g of benzenesulfonyl chloride was stirred overnight with 2 ml of pyridine. The resulting, red colored suspension was poured into 25 ml of 1N hydrochloric acid and the solid which thereby separated was filtered off and dissolved in a mixture of 20 ml of ethanol and 20 ml of 2N sodium hydroxide solution. After the addition of 0.5 g of active charcoal the mixture was stirred at room temperature for 30 minutes and subsequently the active charcoal was filtered off. The product separated as an oil upon neutralization and was thereupon again treated with active charcoal. The product separated upon renewed neutralization with concentrated hydrochloric acid. Recrystallization from 10 ml of 50% ethanol yeilded 0.06 g of N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benzenesulfonamide as yellowish crystals.

1. customthe solid which thereby separated
2. filtrationwas filtered off
3. dissolutiondissolved in a mixture of 20 ml of ethanol and 20 ml of 2N sodium hydroxide solution
4. additionAfter the addition of 0.5 g of active charcoal the mixture
5. filtrationsubsequently the active charcoal was filtered off
6. customThe product separated as an oil upon neutralization
7. additionwas thereupon again treated with active charcoal
8. customThe product separated
9. customRecrystallization from 10 ml of 50% ethanol