反应详情

温度

178 °C

Mixture of 8-methoxy-10,10-dimethyl-10H-11-oxa-4-aza-benzo[b] fluoren-5-one (Compound GT15-4, 25 mg) and pyridine hydrochloric acid salt (492 mg) was stirred and heated at 178° C. overnight. The reaction mixture was cooled, and added with water. The mixture was neutralized with saturated aqueous solution of sodium bicarbonate and extracted with DCM. The organic layer was washed with saturated brine, and then concentrated under reduced pressure. The resulting residues were purified by silica gel column (DCM/MeOH) to obtain the title compound (13 mg, 54%).

1. temperatureThe reaction mixture was cooled
2. extractionextracted with DCM
3. washThe organic layer was washed with saturated brine
4. concentrationconcentrated under reduced pressure
5. customThe resulting residues were purified by silica gel column (DCM/MeOH)