HCID 9837522, compound → HCID 21845565, compound

HRID 619067Notes

Reaction equation

HRID 619067 reaction equation
[NH2:1][C:2](=[S:14])[NH:3][S:4]([C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1)(=[O:6])=[O:5].Br[CH2:16][C:17]([C:19]1[CH:24]=[C:23]([N+:25]([O-:27])=[O:26])[C:22]([OH:28])=[C:21]([OH:29])[CH:20]=1)=O>C(O)C>[OH:29][C:21]1[CH:20]=[C:19]([C:17]2[N:1]=[C:2]([NH:3][S:4]([C:7]3[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=3)(=[O:5])=[O:6])[S:14][CH:16]=2)[CH:24]=[C:23]([N+:25]([O-:27])=[O:26])[C:22]=1[OH:28]

Participants

4

Reactant 2

HCID 9837522HCID 9837522, compoundHCID 218455962-Bromo-1-(3,4-dihydroxy-5-nitro-phenyl)-ethanone

Product 1

HCID 21845565HCID 21845565, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 0.24 g of N-(aminothioxomethyl)-4-methyl-benzene-sulfonamide and 0.2 g of 2-bromo-1-(3,4-dihydroxy-5-nitrophenyl)ethanone was dissolved in 5 ml of ethanol and boiled under reflux for 1 h. 0.26 g of N-[4-(3,4-dihydroxy-5-nitro-phenyl)-thiazol-2-yl]-4-methyl-benzenesulfonamide separated as red crystals upon cooling.

Workup

  1. temperatureunder reflux for 1 h
  2. custom0.26 g of N-[4-(3,4-dihydroxy-5-nitro-phenyl)-thiazol-2-yl]-4-methyl-benzenesulfonamide separated as red crystals
  3. temperatureupon cooling

Sources & evidence

ORD record
ord-ddb20a425e244866b1c3680cb05ff0bd
Source dataset
uspto-grants-1999_09
Patent number
US05958910

Reaction notes

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