反应详情

温度

0 °C

A solution of 7.2 g of 2-bromo-1-(3-fluoro-5-trifluoromethyl-phenyl)-ethanone in 60 ml of methanol was treated at room temperature with 2.7 g of thiourea and boiled for 1 hour. 5.2 g of 4-(3-fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals upon cooling to 0° C. and after the addition of 15 ml of diethyl ether.

1. custom5.2 g of 4-(3-fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals
2. additionafter the addition of 15 ml of diethyl ether