Thiourea → 4-(3-Fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide
Reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([F:15])[CH:6]=1)=O.[NH2:16][C:17]([NH2:19])=[S:18]>CO>[BrH:1].[F:15][C:7]1[CH:6]=[C:5]([C:3]2[N:16]=[C:17]([NH2:19])[S:18][CH:2]=2)[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
A solution of 7.2 g of 2-bromo-1-(3-fluoro-5-trifluoromethyl-phenyl)-ethanone in 60 ml of methanol was treated at room temperature with 2.7 g of thiourea and boiled for 1 hour. 5.2 g of 4-(3-fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals upon cooling to 0° C. and after the addition of 15 ml of diethyl ether.
Workup
- custom5.2 g of 4-(3-fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals
- additionafter the addition of 15 ml of diethyl ether
Sources & evidence
- ORD record
- ord-2a2f8ee9627a43868c8988f663f1fa99
- Source dataset
- uspto-grants-1999_09
- Patent number
- US05958910
Reaction notes
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