HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 619078Generated: November 1, 2026
Thiourea → 4-(3-Fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide
https://huagongshe.com/reaction/619078
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 2-Bromo-1-(3-fluoro-5-(trifluoromethyl)phenyl)ethan-1-one | HCID 2778930 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(3-Fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide | HCID 21845579 | — |
Reaction Steps
A solution of 7.2 g of 2-bromo-1-(3-fluoro-5-trifluoromethyl-phenyl)-ethanone in 60 ml of methanol was treated at room temperature with 2.7 g of thiourea and boiled for 1 hour. 5.2 g of 4-(3-fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals upon cooling to 0° C. and after the addition of 15 ml of diethyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05958910 |
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| Source dataset | uspto-grants-1999_09 |
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| ORD ID | ord-2a2f8ee9627a43868c8988f663f1fa99 |
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| Source note | uspto-grants-1999_09 |
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