4-(4-Hydroxyphenyl)thiomorpholine 1,1-Dioxide → HCID 21845220, compound

HRID 619097Notes

Reaction equation

HRID 619097 reaction equation
[O:1]=[S:2]1(=[O:15])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[CH2:16]([O:28][CH2:29][CH:30]1[O:32][CH2:31]1)[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH:25]([CH3:27])[CH3:26]>[Br-].C([P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)C>[O:15]=[S:2]1(=[O:1])[CH2:3][CH2:4][N:5]([C:8]2[CH:9]=[CH:10][C:11]([O:14][CH2:31][CH:30]([OH:32])[CH2:29][O:28][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH:25]([CH3:27])[CH3:26])=[CH:12][CH:13]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 218452234-(4-Hydroxyphenyl)thiomorpholine 1,1-DioxideHCID 86210289HCID 86210289, compound

Product 1

HCID 21845220HCID 21845220, compoundYield 30%

Reagents, catalysts & solvents 1

HCID 73727Phosphonium, ethyltriphenyl-, bromide (1:1)Catalyst

Procedure

4-(1,1-dioxo-thiomorpholin-4-yl)phenol (2.3 g, 10 mmol), isododecylglycidyl ether (2.4 g, 10 mmol) and ethyltriphenylphosphonium bromide (0.2 g) are reacted and purified as described for compound 102 to afford a light yellow liquid 1.4 g (30%).

Workup

  1. custompurified

Sources & evidence

ORD record
ord-9439b19ffe10473b9f9cc703fdd8824a
Source dataset
uspto-grants-1999_09
Patent number
US05958663

Reaction notes

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