Phenyl glycidyl ether → HCID 21845233, compound

HRID 619098Notes

Reaction equation

HRID 619098 reaction equation
[O:1]=[S:2]1(=[O:15])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[C:16]1([O:22][CH2:23][CH:24]2[O:26][CH2:25]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>[Br-].C([P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)C>[O:15]=[S:2]1(=[O:1])[CH2:3][CH2:4][N:5]([C:8]2[CH:9]=[CH:10][C:11]([O:14][CH2:25][CH:24]([OH:26])[CH2:23][O:22][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:12][CH:13]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 31217Phenyl glycidyl etherHCID 218452234-(4-Hydroxyphenyl)thiomorpholine 1,1-Dioxide

Product 1

HCID 21845233HCID 21845233, compoundYield 58.3%

Reagents, catalysts & solvents 1

HCID 73727Phosphonium, ethyltriphenyl-, bromide (1:1)Catalyst

Procedure

4-(1,1-dioxo-thiomorpholin-4-yl)phenol (2.3 g, 10 mmol), phenylglycidyl ether(1.5 g, 10 mmol) and ethyltriphenylphosphonium bromide (0.1 g) are reacted and purified as described for compound 102 to afford a light yellow liquid 2.2 g (58%).

Workup

  1. custompurified

Sources & evidence

ORD record
ord-a099c38cb4bb492a8a47b219af37dc7c
Source dataset
uspto-grants-1999_09
Patent number
US05958663

Reaction notes

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