Pyridine → HCID 86752774, compound

HRID 619103Notes

Reaction equation

HRID 619103 reaction equation
COC1C=CC(N(OC(C)C(O)C)OC(C)C(O)C)=C(CCC)C=1.N1C=CC=CC=1.CN(C1C=CC=CN=1)C.C1(P(Cl)Cl)C=CC=CC=1.[CH2:49]([O:53][CH2:54][CH:55]1[CH2:62][N:61]([C:63]2[CH:68]=[CH:67][C:66]([O:69][CH2:70]CCCCCCCCCCC)=[CH:65][CH:64]=2)[CH2:60][CH:59]([CH2:82][O:83][CH2:84][CH2:85][CH2:86][CH3:87])[O:58][P:57](=[O:94])([C:88]2[CH:93]=[CH:92][CH:91]=[CH:90][CH:89]=2)[O:56]1)[CH2:50][CH2:51][CH3:52]>ClCCl>[CH2:84]([O:83][CH2:82][CH:59]1[CH2:60][N:61]([C:63]2[CH:68]=[CH:67][C:66]([O:69][CH3:70])=[CH:65][CH:64]=2)[CH2:62][CH:55]([CH2:54][O:53][CH2:49][CH2:50][CH2:51][CH3:52])[O:56][P:57](=[O:94])([C:88]2[CH:89]=[CH:90][CH:91]=[CH:92][CH:93]=2)[O:58]1)[CH2:85][CH2:86][CH3:87]

Participants

7

Reactant 5

HCID 1049PyridineHCID 12573Phenyl phosphorus dichlorideHCID 218852-DimethylaminopyridineHCID 54485562HCID 54485562, compoundHCID 86752773HCID 86752773, compound

Product 1

HCID 86752774HCID 86752774, compoundYield 24%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

It is prepared from 4-methoxy-N,N-di(2-hydroxy-3-butoxy)-propyl aniline (1.91 g, 5 mmol), pyridine (1.2 g, 15 mmol), dimethylaminopyridine (0.2 g) and phenylphosphonous dichloride (1 g, 5.1 mmol) in dichloromethane as described for compound 200 to obtain a colourless liquid 0.6 g (24%) and its isomer 0.6 g (24% a colourless liquid).

Sources & evidence

ORD record
ord-17f0765332d04b73a19ce0abec337f24
Source dataset
uspto-grants-1999_09
Patent number
US05958663

Reaction notes

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