Diethyl Ether → HCID 86754544, compound

HRID 619127Notes

Reaction equation

HRID 619127 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[S:34][C:12]2=[N:13][C:14]([CH3:33])=[C:15]([C:25]([O:27][CH2:28][CH2:29][N:30]([CH3:32])[CH3:31])=[O:26])[CH:16]([C:17]3[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=3)[N:11]2[CH:10]=1.C(OCC)C>Cl>[ClH:1].[ClH:1].[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[C:9]1[S:34][C:12]2=[N:13][C:14]([CH3:33])=[C:15]([C:25]([O:27][CH2:28][CH2:29][N:30]([CH3:32])[CH3:31])=[O:26])[CH:16]([C:17]3[CH:18]=[CH:19][C:20]([O:23][CH3:24])=[CH:21][CH:22]=3)[N:11]2[CH:10]=1

Participants

4

Reactant 2

HCID 3283Diethyl EtherHCID 15392101HCID 15392101, compound

Product 1

HCID 86754544HCID 86754544, compoundYield 275.8%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

0.83 g (1.6 mmol) of 2-dimethylamino-ethyl (RS)-2-(2,6-dichlorophenyl)-5-(4-methoxyphenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate was dissolved in 10 ml of methanolic hydrochloric acid solution (2.6N) while stirring and treated with 50 ml of diethyl ether. After 3 h. the crystals were filtered off. There was obtained 0.87 g (79%) of 2-dimethylamino-ethyl (RS)-2-(2,6-dichlorophenyl)-5-(4-methoxyphenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate dihydrochloride as a beige solid with m.p.>240° C.

Workup

  1. filtrationAfter 3 h. the crystals were filtered off

Sources & evidence

ORD record
ord-1fb8c5ad62b646488000cd0ae00dcf2d
Source dataset
uspto-grants-1999_09
Patent number
US05958931

Reaction notes

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