Water → HCID 54456186, compound

HRID 619128Notes

Reaction equation

HRID 619128 reaction equation
[CH3:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.Cl.[NH2:11][C:12]([NH2:14])=[NH:13].O>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[N:13][C:12](=[NH:14])[N:11]=[CH:1][C:2]2[CH:9]=[CH:8][C:5]([CH3:6])=[CH:4][CH:3]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 5742Guanidine HydrochlorideHCID 77254-Methylbenzaldehyde

Product 1

HCID 54456186HCID 54456186, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

4-Methylbenzaldehyde (MBA) (0.50 mols-60 grams) is admixed with guanidine hydrochloride (0.25 mols, 25 grams) in molar ratio of 2:1. They are then heated under reflux in 150 ml of toluene under a Dean Stark water collector trap for approximately 17 hours to collect the theoretical amount of H2 0 evolved. The hot solution is rapidly decanted to ensure the removal of insoluble residues. The solution is then evaporated to dryness on a rotary evaporator. The crude immine is then recrystalized twice from absolute ethanol.

Workup

  1. temperatureThey are then heated
  2. customto collect the theoretical amount of H2 0
  3. customThe hot solution is rapidly decanted
  4. customthe removal of insoluble residues
  5. customThe solution is then evaporated to dryness on a rotary evaporator
  6. customThe crude immine is then recrystalized twice from absolute ethanol

Sources & evidence

ORD record
ord-f56b1f91c9214aa7b167697afce315aa
Source dataset
uspto-grants-1999_09
Patent number
US05958933

Reaction notes

Loading…