反应详情

To a mixture of imidazole (5.13 g, 75.35 mmol), K2CO3 (11.45 g) and DMSO (50 ml) at room temperature was added to 4-fluorobenzonitrile (10.04 g) in one portion. The reaction mixture was stirred at room temperature for 1 hour, and then was warmed on a steam for 2 hours. The reaction mixture was cooled to room temperature, and poured into cold water. A precipitate formed which was collected by filtration and washed with water and recrystallized from CHCl3 /hexane to afford 4.07 g of 4-(1-imidazolyl)benzonitrile, m.p. 146-148° C.

1. temperaturewas warmed on a steam for 2 hours
2. temperatureThe reaction mixture was cooled to room temperature
3. customA precipitate formed which
4. filtrationwas collected by filtration
5. washwashed with water
6. customrecrystallized from CHCl3 /hexane