Dichloromethane → HCID 66834435, compound

HRID 61915Notes

Reaction equation

HRID 61915 reaction equation
C(Cl)Cl.[O:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH:6]=[C:5]1[C:13]([C:16]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:17]=1[C:18]([OH:20])=O)([CH3:15])[CH3:14].FC(F)(F)C(OC(=O)C(F)(F)F)=O>O>[CH3:26][O:25][C:22]1[CH:21]=[C:17]2[C:16]([C:13]([CH3:15])([CH3:14])[C:5]3[O:4][C:8]4[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=4[C:6]=3[C:18]2=[O:20])=[CH:24][CH:23]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 9845Trifluoroacetic anhydrideHCID 66834951HCID 66834951, compound

Product 1

HCID 66834435HCID 66834435, compoundYield 84.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To the DCM solution (1 ml) of 2-(1-benzofuran-2-yl-1-methylethyl)-5-methoxy benzoic acid (63 mg), trifluoroacetic anhydride (0.03 ml) was added at room temperature under nitrogen atmosphere. The mixture was stirred for 30 min. The reaction mixture was then added with water and extracted with DCM. The organic layer was dried over sodium sulfate. The residues obtained after concentration under reduced pressure were purified by silica gel column (DCM) to obtain the title compound (50 mg, 84%).

Workup

  1. extractionextracted with DCM
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. customThe residues obtained
  4. concentrationafter concentration under reduced pressure
  5. customwere purified by silica gel column (DCM)

Sources & evidence

ORD record
ord-e92e836df69a4669b74926d293a1a831
Source dataset
uspto-grants-2016_09
Patent number
US09440922B2

Reaction notes

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