反应详情

To the DCM solution (1 ml) of 2-(1-benzofuran-2-yl-1-methylethyl)-5-methoxy benzoic acid (63 mg), trifluoroacetic anhydride (0.03 ml) was added at room temperature under nitrogen atmosphere. The mixture was stirred for 30 min. The reaction mixture was then added with water and extracted with DCM. The organic layer was dried over sodium sulfate. The residues obtained after concentration under reduced pressure were purified by silica gel column (DCM) to obtain the title compound (50 mg, 84%).

1. extractionextracted with DCM
2. dry with materialThe organic layer was dried over sodium sulfate
3. customThe residues obtained
4. concentrationafter concentration under reduced pressure
5. customwere purified by silica gel column (DCM)