HCID 178458291, compound → 6-(2-Propoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-one

HRID 619159Notes

Reaction equation

HRID 619159 reaction equation
C([N:5]1[C:9]2=[N:10][C:11]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[O:21][CH2:22][CH2:23][CH3:24])=[N:12][C:13](=[O:14])[C:8]2=[CH:7][NH:6]1)(C)(C)C>FC(F)(F)C(O)=O>[CH2:22]([O:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:11]1[N:10]=[C:9]2[N:5]=[N:6][CH:7]=[C:8]2[C:13](=[O:14])[N:12]=1)[CH2:23][CH3:24]

Participants

3

Reactant 1

HCID 178458291HCID 178458291, compound

Product 1

HCID 867523636-(2-Propoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-oneYield 79.9%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of 1-tert-butyl-6-(2-propoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-one 1/100 hydrate (0.68 g, 2.1 mmol) and trifluoroacetic acid (50 ml) was heated on a steam bath for 3.5 hours. The reaction mixture was stripped to dryness and the residue was purified by column chromatography on silica gel eluting with ether to afford 0.45 g (79%) of 6-(2-propoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-one.1/4 hydrate, m.p. 170-171° C.

Workup

  1. temperaturewas heated on a steam bath for 3.5 hours
  2. customthe residue was purified by column chromatography on silica gel eluting with ether

Sources & evidence

ORD record
ord-a480df47de9447efa2e96d1d9d7c15c6
Source dataset
uspto-grants-1999_09
Patent number
US05958929

Reaction notes

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