Hydrochloric Acid → HCID 21846482, compound

HRID 619204Notes

Reaction equation

HRID 619204 reaction equation
N=[C:2]1[C:6]2([CH2:11][CH2:10][S:9][CH2:8][CH2:7]2)[NH:5][C:4](=[O:12])[N:3]1[C:13]1[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[C:15]([C:21]([F:24])([F:23])[F:22])[CH:14]=1.C[OH:26].Cl>C(Cl)(Cl)Cl>[O:12]=[C:4]1[N:3]([C:13]2[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[C:15]([C:21]([F:24])([F:23])[F:22])[CH:14]=2)[C:2](=[O:26])[C:6]2([CH2:11][CH2:10][S:9][CH2:8][CH2:7]2)[NH:5]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 21846485HCID 21846485, compound

Product 1

HCID 21846482HCID 21846482, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Using the procedure of Example 2, 2.34 g of the product of Example 12, 25 ml of methanol and 5 ml of chloroform were reacted and 4.5 ml of 2N hydrochloric acid were added. The reaction medium was refluxed for one hour and after purification on silica with methylene chloride-acetone: 95-5 as eluant, crystallization from isopropanol was carried out to obtain 368 mg of the expected product (white crystals) melting at 209-210° C.

Workup

  1. customwere reacted
  2. temperatureThe reaction medium was refluxed for one hour
  3. customafter purification on silica with methylene chloride-acetone
  4. custom95-5 as eluant, crystallization from isopropanol

Sources & evidence

ORD record
ord-fca116afdf8b42f6b24cae343da48349
Source dataset
uspto-grants-1999_09
Patent number
US05958936

Reaction notes

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