Hydrochloric Acid → HCID 69823416, compound

HRID 619256Notes

Reaction equation

HRID 619256 reaction equation
C([NH:4][C@@H:5]([C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=[O:12])=[CH:9][C:8]=1[Cl:17])[CH3:6])(=O)C.Cl>>[ClH:17].[NH2:4][C@@H:5]([C:7]1[CH:16]=[CH:15][C:10]([C:11]([OH:13])=[O:12])=[CH:9][C:8]=1[Cl:17])[CH3:6]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 12109165HCID 12109165, compound

Product 1

HCID 69823416HCID 69823416, compoundYield 240.7%

Procedure

Methyl (R)-4-(1-acetamidoethyl)-3-chlorobenzoate (630 mg) was added to 2N hydrochloric acid (15 ml), and the mixture was refluxed for 3 hours. After the reaction, the solvent was evaporated under reduced pressure. The residue was further boiled with toluene, and dried to give 700 mg of (R)-4-(1-aminoethyl)-3-chlorobenzoic acid hydrochloride.

Workup

  1. temperaturethe mixture was refluxed for 3 hours
  2. customAfter the reaction
  3. customthe solvent was evaporated under reduced pressure
  4. customdried

Sources & evidence

ORD record
ord-b2afcb844166443f8ed96566367afa62
Source dataset
uspto-grants-1999_09
Patent number
US05958944

Reaction notes

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