Hydrochloric Acid → HCID 69823626, compound

HRID 619270Notes

Reaction equation

HRID 619270 reaction equation
C([NH:4][C@@H:5]([C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=[O:12])=[CH:9][C:8]=1[F:17])[CH3:6])(=O)C.[ClH:18]>>[ClH:18].[NH2:4][C@@H:5]([C:7]1[CH:16]=[CH:15][C:10]([C:11]([OH:13])=[O:12])=[CH:9][C:8]=1[F:17])[CH3:6]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 12109153HCID 12109153, compound

Product 1

HCID 69823626HCID 69823626, compound

Procedure

Methyl (R)-4-(1-acetamidoethyl)-3-fluorobenzoate (690 mg) was added to 2N hydrochloric acid (15 ml), and the mixture was refluxed for 3 hours. After the reaction, the reaction mixture was evaporated under reduced pressure, further boiled with toluene, and dried to give (R)-4-(1-aminoethyl)-3-fluorobenzoic acid hydrochloride (620 mg).

Workup

  1. temperaturethe mixture was refluxed for 3 hours
  2. customAfter the reaction
  3. customthe reaction mixture was evaporated under reduced pressure
  4. customdried

Sources & evidence

ORD record
ord-e7b4f52353634272bf7d351173bc34f8
Source dataset
uspto-grants-1999_09
Patent number
US05958944

Reaction notes

Loading…