Hydrochloric Acid → HCID 21198552, compound

Participants

Reaction Steps

To 1.46 g of 4-(2-carboxyethyl)-1-[(ethoxycarbonyl)methyl]-piperidine in 10 ml methylene chloride, is added 1 ml of saturated ethereal hydrochloric acid. 1.2 g of thionyl chloride are added and the mixture is stirred for 3 hours at ambient temperature. The reaction mixture is concentrated by evaporation and the residue is mixed twice with toluene and evaporated down again. The crude product is further reacted in Examples 1 and 2 without being purified.

Provenance & Evidence