Hydrochloric Acid → HCID 21198552, compound

HRID 619279Notes

Reaction equation

HRID 619279 reaction equation
[C:1]([CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:8][CH2:7]1)(O)=[O:2].[ClH:18].S(Cl)([Cl:21])=O>C(Cl)Cl>[ClH:21].[Cl:18][C:1]([CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:8][CH2:7]1)=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24386Thionyl ChlorideHCID 15818985HCID 15818985, compound

Product 1

HCID 21198552HCID 21198552, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 1.46 g of 4-(2-carboxyethyl)-1-[(ethoxycarbonyl)methyl]-piperidine in 10 ml methylene chloride, is added 1 ml of saturated ethereal hydrochloric acid. 1.2 g of thionyl chloride are added and the mixture is stirred for 3 hours at ambient temperature. The reaction mixture is concentrated by evaporation and the residue is mixed twice with toluene and evaporated down again. The crude product is further reacted in Examples 1 and 2 without being purified.

Workup

  1. concentrationThe reaction mixture is concentrated by evaporation
  2. additionthe residue is mixed twice with toluene
  3. customevaporated down again
  4. customThe crude product is further reacted in Examples 1 and 2
  5. customwithout being purified

Sources & evidence

ORD record
ord-53d9442626b3418c838ecbc191ab7200
Source dataset
uspto-grants-1999_09
Patent number
US05958952

Reaction notes

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