反应详情

2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine (288.3 mg) was dissolved in benzene (50 mL) and phenyl isocyanate (119.1 mg) was added. The reaction mixture was heated to reflux for 48 hours, and the solvent was removed under vacuum. The residue was chromatographed on silica gel, eluting with hexane/ethyl acetate, to yield 1-[4-(4-fluoronaphth-1-yl)-6-isopropyl-pyrimidin-2-yl]-3-phenylurea (49.1 mg), m.p. 117-178° C.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 48 hours
3. customthe solvent was removed under vacuum
4. customThe residue was chromatographed on silica gel
5. washeluting with hexane/ethyl acetate