HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl isocyanate → HCID 21846256, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl isocyanate | HCID 7672 | — |
| Reactant | 4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine | HCID 196968 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 21846256 | HCID 21846256 | 12.3% |
Reaction Steps
2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine (288.3 mg) was dissolved in benzene (50 mL) and phenyl isocyanate (119.1 mg) was added. The reaction mixture was heated to reflux for 48 hours, and the solvent was removed under vacuum. The residue was chromatographed on silica gel, eluting with hexane/ethyl acetate, to yield 1-[4-(4-fluoronaphth-1-yl)-6-isopropyl-pyrimidin-2-yl]-3-phenylurea (49.1 mg), m.p. 117-178° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05958934 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-0142468878844fe18a4187f98218ebe5 |
| Source note | uspto-grants-1999_09 |