反应详情

温度

125 °C

A mixture of the above acetonitrile (5.40 g, 32 mmol), ammonium chloride (2.59 g, 48 mmol) and sodium azide (3.15 g, 48 mmol) in N,N'-dimethylformamide (100 ml) was stirred at 125° C. for 16 hours. After cooling the mixture was poured into water (300 ml) and extracted with ethyl acetate (2×150 ml) The combined organic phases were washed with water (100 ml) and evaporated in vacuo. The residue was crystallised from diethyl ether (20 ml), filtered off and washed with diethyl ether affording 1.86 g (27%) of the title compound as a solid.

1. temperatureAfter cooling the mixture
2. extractionextracted with ethyl acetate (2×150 ml) The combined organic phases
3. washwere washed with water (100 ml)
4. customevaporated in vacuo
5. customThe residue was crystallised from diethyl ether (20 ml)
6. filtrationfiltered off
7. washwashed with diethyl ether affording 1.86 g (27%) of the title compound as a solid