Hydrazine hydrate (1:1) → HCID 21995356, compound

HRID 619361Notes

Reaction equation

HRID 619361 reaction equation
C1(=O)[N:5]([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][N:19]=[C:18]([NH:22][C:23]4[CH:28]=[C:27]([O:29][CH3:30])[C:26]([O:31][CH3:32])=[C:25]([O:33][CH3:34])[CH:24]=4)[N:17]=3)=[CH:12][CH:11]=2)C(=O)C2=CC=CC=C12.O.NN>>[NH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][N:19]=[C:18]([NH:22][C:23]3[CH:28]=[C:27]([O:29][CH3:30])[C:26]([O:31][CH3:32])=[C:25]([O:33][CH3:34])[CH:24]=3)[N:17]=2)=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21995252HCID 21995252, compound

Product 1

HCID 21995356HCID 21995356, compoundYield 28.4%

Procedure

The compound was prepared in a manner analogous to the preparation of the compound of Example 48 from the compound of Example 50 (830 mg, 1 .54 mmol) and hydrazine monohydrate (0.23 ml, 4.62 mmol) to give the title compound (63 mg) as a white solid m.p. 161-162°. MS m/z 411 (M+H)+.

Sources & evidence

ORD record
ord-f8459973549a4e7ca2e68f295af393ba
Source dataset
uspto-grants-1999_09
Patent number
US05958935

Reaction notes

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