Hydrochloric Acid → HCID 21190072, compound

HRID 619437Notes

Reaction equation

HRID 619437 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[N:13]3[C:8]([C:9](=[O:27])[N:10]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][S:20]([C:23]([F:26])([F:25])[F:24])(=[O:22])=[O:21])[C:11](=[O:14])[C:12]=13)=[CH:7][CH:6]=[CH:5]2.[ClH:28]>CO>[ClH:28].[CH3:1][C:2]1[N:3]=[C:4]2[N:13]3[C:8]([C:9](=[O:27])[N:10]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][S:20]([C:23]([F:25])([F:26])[F:24])(=[O:21])=[O:22])[C:11](=[O:14])[C:12]=13)=[CH:7][CH:6]=[CH:5]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190073HCID 21190073, compound

Product 1

HCID 21190072HCID 21190072, compoundYield 88.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 816 mg (2.02 mmol) of 4,5-dihydro-2-methyl-4-[4-(trifluoromethanesulfonamido) butan-1-yl]-3H-1,4,8b-triazaacenaphthylene-3,5-dione in 10 ml of methanol was added 0.34 ml of conc. HCl, and the solvent was distilled off. To the residue was added acetone, and the resulting solid was washed with acetone, dried to give 790 mg of the desired compound (88.8%, colorless solid), m.p.181.0-182.0° C.

Workup

  1. distillationthe solvent was distilled off
  2. additionTo the residue was added acetone
  3. washthe resulting solid was washed with acetone
  4. customdried

Sources & evidence

ORD record
ord-ddaefb6c429f484faaa5d9baeed760cd
Source dataset
uspto-grants-1999_09
Patent number
US05958942

Reaction notes

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