Hydrochloric Acid → HCID 21190205, compound

HRID 619439Notes

Reaction equation

HRID 619439 reaction equation
[F:1][C:2]([F:27])([F:26])[CH2:3][S:4]([NH:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:22](=[O:23])[C:21]2[N:24]3[C:14](=[CH:15][N:16]=[C:17]3[CH:18]=[CH:19][CH:20]=2)[C:13]1=[O:25])(=[O:6])=[O:5].[ClH:28]>CO>[ClH:28].[F:27][C:2]([F:1])([F:26])[CH2:3][S:4]([NH:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:22](=[O:23])[C:21]2[N:24]3[C:14](=[CH:15][N:16]=[C:17]3[CH:18]=[CH:19][CH:20]=2)[C:13]1=[O:25])(=[O:6])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190206HCID 21190206, compound

Product 1

HCID 21190205HCID 21190205, compoundYield 90.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 440 mg (1.09 mmol) of 4,5-dihydro-4-[4-[(2,2,2-trifluoro)ethanesulfonamido]butan-1-yl]-3H-1,4,8b-triazaacenaphthylene-3,5-dione in 20 ml of methanol was added 0.15 ml of conc. HCl, and the solvent was distilled off. To the residue was added acetone, and the resulting solid product was collected by filtration, followed by washing with acetone and drying to give 435 mg of the desired compound (90.6%, colorless solid), m.p.154.0-155.0° C.

Workup

  1. distillationthe solvent was distilled off
  2. additionTo the residue was added acetone
  3. filtrationthe resulting solid product was collected by filtration
  4. washby washing with acetone
  5. customdrying

Sources & evidence

ORD record
ord-18f70271aa95477aaeaafbd6a7f936fa
Source dataset
uspto-grants-1999_09
Patent number
US05958942

Reaction notes

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