Hydrochloric Acid → HCID 70212814, compound

HRID 619444Notes

Reaction equation

HRID 619444 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]3[N:5]2[C:6]=1[C:7](=[O:24])[N:8]3[CH2:13][CH2:14][CH2:15][NH:16][S:17]([C:20]([F:23])([F:22])[F:21])(=[O:19])=[O:18].[ClH:25]>CO>[ClH:25].[CH3:1][C:2]1[N:3]=[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]3[N:5]2[C:6]=1[C:7](=[O:24])[N:8]3[CH2:13][CH2:14][CH2:15][NH:16][S:17]([C:20]([F:21])([F:22])[F:23])(=[O:19])=[O:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190103HCID 21190103, compound

Product 1

HCID 70212814HCID 70212814, compoundYield 88.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 866 mg (2.39 mmol) of 1,2-dihydro-3-methyl-1-[3-(trifluoromethanesulfonamido)propan-1-yl]-1,4,7b-triazacyclopent[cd]inden-2-one in 20 ml of methanol was added 0.24 ml of conc. HCl. The solvent was then distilled off. To the residue were added ethanol, acetone and ether. The resulting solid was washed with ether and, then dried to give 844 mg of the desired compound (88.6%, pale yellow solid), m.p.145.0-146° C.

Workup

  1. distillationThe solvent was then distilled off
  2. additionTo the residue were added ethanol, acetone and ether
  3. washThe resulting solid was washed with ether
  4. customdried

Sources & evidence

ORD record
ord-67a3c07c63fc4b03b09ace2b24260b8f
Source dataset
uspto-grants-1999_09
Patent number
US05958942

Reaction notes

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