Hydrochloric Acid → HCID 70211085, compound

HRID 619447Notes

Reaction equation

HRID 619447 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]3[N:5]2[C:6]=1[C:7](=[O:27])[N:8]3[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][S:20]([C:23]([F:26])([F:25])[F:24])(=[O:22])=[O:21].[ClH:28]>CO>[ClH:28].[CH3:1][C:2]1[N:3]=[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]3[N:5]2[C:6]=1[C:7](=[O:27])[N:8]3[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][S:20]([C:23]([F:25])([F:24])[F:26])(=[O:22])=[O:21]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190231HCID 21190231, compound

Product 1

HCID 70211085HCID 70211085, compoundYield 83.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 623 mg (1.54 mmol) of 1,2-dihydro-3-methyl-1-[6-(trifluoromethanesulfonamido) hexan-1-yl]-1,4,7b-triazacyclopent[cd]inden-2-one in 10 ml of methanol was added 0.16 ml of conc. HCl and, then, the solvent was distilled off. To the residue were added acetone and ether. The resulting solid was washed with ether, dried to give 570 mg of the desired compound (83.9%, pale yellow solid).

Workup

  1. distillationthe solvent was distilled off
  2. additionTo the residue were added acetone and ether
  3. washThe resulting solid was washed with ether
  4. customdried

Sources & evidence

ORD record
ord-1b603a52c1fc4647a1c975b000b737af
Source dataset
uspto-grants-1999_09
Patent number
US05958942

Reaction notes

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