Hydrochloric Acid → HCID 70213341, compound

HRID 619460Notes

Reaction equation

HRID 619460 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]3[N:5]2[C:6]=1[C:7](=[O:28])[N:8]3[CH2:13][CH2:14][C:15]([CH3:27])([CH3:26])[CH2:16][CH2:17][NH:18][S:19]([C:22]([F:25])([F:24])[F:23])(=[O:21])=[O:20].[ClH:29]>CO>[ClH:29].[CH3:1][C:2]1[N:3]=[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]3[N:5]2[C:6]=1[C:7](=[O:28])[N:8]3[CH2:13][CH2:14][C:15]([CH3:26])([CH3:27])[CH2:16][CH2:17][NH:18][S:19]([C:22]([F:23])([F:24])[F:25])(=[O:20])=[O:21]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190175HCID 21190175, compound

Product 1

HCID 70213341HCID 70213341, compoundYield 82.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1.03 g (2.46 mmol) of 1,2-dihydro-3-methyl-1-[3,3-dimethyl-5-(trifluoromethanesulfonamido)pentan-1-yl]-1,4,7b-triazacyclopent[cd]inden-2-one in 30 ml of methanol was added 0.29 ml (3.5 mmol) of conc. HCl. The solvent was distilled off, and the residue was recrystallized (solvent: ethanol/diethylether) to give 0.928 g of the desired compound (82.9%, pale yellow powdery substance), m.p.162.0-165.0° C.

Workup

  1. distillationThe solvent was distilled off
  2. customthe residue was recrystallized (solvent: ethanol/diethylether)

Sources & evidence

ORD record
ord-82244e72503b49c582b39b961b04db9b
Source dataset
uspto-grants-1999_09
Patent number
US05958942

Reaction notes

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