反应详情

To a solution of 2.58 g (10.0 mmol) of 3-methyl-1-[5-(amino)pentan-1-yl]-1,4,7b-triazacyclopent[cd]inden-2-one and 1.81 ml (13.0 mmol) of triethylamine in 100 ml of acetonitrile was added, while stirring at room temperature, 2.31 g (12.0 mmol) of pentafluoropropionic acid ethyl ester. The mixture was stirred for 4 hours at the same temperature. The solvent was distilled off. To the residue was added methylene chloride, and the mixture was washed with water, and dried over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified by column chromatography (eluent: ethyl acetate) to afford 2.04 g of the desired compound (50.4%, a pale yellow solid).

1. stirringThe mixture was stirred for 4 hours at the same temperature
2. distillationThe solvent was distilled off
3. additionTo the residue was added methylene chloride
4. washthe mixture was washed with water
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationThe solvent was distilled off
7. customthe residue was purified by column chromatography (eluent: ethyl acetate)